Without Parole will miss the Qipco 2000 Guineas at Newmarket on Saturday after suffering a bruised foot, trainer John Gosden confirmed.
An impressive winner on his sole juvenile appearance at Newcastle in December, the son of Frankel made a successful reappearance at Yarmouth last week and was a general 12-1 shot for the first colts’ Classic of the year.
Gosden told Press Association Sport: “I spoke to the owners in America. He has got a little bruise in his right front foot, just in the heel.
“There is a bit of heat and a little bit of tenderness. It’s not a big thing but he ain’t going to be running in a Guineas.
“It’s early in the year and there is no need to panic.”
The Clarehaven handler added: “It could have brewed up from the race at Yarmouth. Like any little bruise it comes there and pops into a little abscess form. It’s typical of how a bruise comes. He didn’t go and step on anything.
“I think with a horse like this we will get a nice race in before Royal Ascot, that is the way to look at it I think.
“He is a very nice type of horse and we will treat him with respect.
“Hopefully we’ll freshen him up for the Heron Stakes at Sandown on May 24 and look at the St James’s Palace Stakes at Royal Ascot.”
Gosden could still saddle Roaring Lion in the 2000 Guineas.
He said: “We are going to do a little breeze (on Wednesday) and then make our minds up. I think he has comes on a lot for his last race.”
Without Parole’s defection means Gosden’s number one rider Frankie Dettori is free to partner James Garfield.
The popular Italian was on board when George Scott’s star colt won the Greenham Stakes at Newbury last month, his second big-race success at the Berkshire circuit under Dettori having also landed the Mill Reef last September.
Dettori said: “He has won a Greenham, which is one of the main Guineas trials.
“George is very happy with him and we’ve got to give it a go.
“He is a bonny little horse and he really tries. He wears his heart on his sleeve and he should give it his best.”
Scott said: “I feel for the connections of Without Parole, who clearly has a massive future regardless of missing the Guineas.
“I felt it was hugely important to have Frankie on board. He knows the horse so well and he has a lot of confidence in the horse.
“He is the magic man and if anyone can pull it out the bag he will.”
James Garfield continued his preparation for the weekend when working over six furlongs on the Cambridge Road Polytrack gallop on Tuesday morning.
Scott said: “He has come out of his Newbury run extremely well. Obviously we’ve not done a huge amount of work with him since then. Today was the most he has done and he has come through that lovely.
“He didn’t really have a blow and he was bright and fresh after the work. I’m delighted with that.”
The son of Exceed and Excel has run just once over a mile when he failed to fire in the Breeders’ Cup Juvenile Turf.
Scott said: “I don’t see why he won’t get the mile. His racing style gives him the opportunity to do so and there is plenty of stamina on the dam’s side.
“He has run well on all types of ground. I believe he is better and more effective on top of the ground.”