Last year’s winner Bristol De Mai may face the first two home from the Cheltenham Gold Cup in defence of his Betfair Chase title at Haydock on November 24.
Nigel Twiston-Davies’ grey later struggled to replicate his stunning performance in winning the first leg of the Triple Crown last season, but he has nevertheless been installed as the 9-4 favourite by the sponsors to win back-to-back renewals.
Nicky Henderson’s Might Bite won the King George last season but came up just short at Cheltenham behind Colin Tizzard’s Native River and that pair are next in the betting at 5-2.
Tizzard has also entered his 2016 King George winner Thistlecrack, who has a host of options including the Ladbrokes Trophy and BetVictor Gold Cup.
Paul Nicholls has entered Politologue, Black Corton and Clan Des Obeaux – with Harry Fry’s American and Ms Parfois in the mix too.
Noel Meade’s Disko and the Gordon Elliott trio of Outlander, Don Poli and Shattered Love make up the Irish challenge. All four are owned by Gigginstown House Stud.
David Pipe’s Un Temps Pour Tout completes the list.